Author: Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Title: Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy Document date: 2020_2_27
ID: egntml7e_95
Snippet: Although monocytes/macrophages system plays a vital role in sepsis, the acquired immune system is equally important, and the effect of AS on T and B cells function remains to be investigated in the future. However, given the therapeutic effect of AS on CLP animal models, we firmly believe that AS will improve the function of T and B cells. VDR is an interaction molecule of AS, whether VDR is a drug target of AS remains to be further studied in th.....
Document: Although monocytes/macrophages system plays a vital role in sepsis, the acquired immune system is equally important, and the effect of AS on T and B cells function remains to be investigated in the future. However, given the therapeutic effect of AS on CLP animal models, we firmly believe that AS will improve the function of T and B cells. VDR is an interaction molecule of AS, whether VDR is a drug target of AS remains to be further studied in the future. Overall, our findings provide an evidence that AS interacted with VDR to reverse sepsis-induced immunosuppression in an autophagy and NF-κB dependent way, highlighting a novel approach for sepsis treatment and drug repurposing of AS in the future.
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