Author: Okeke, Malachy I.; Okoli, Arinze S.; Diaz, Diana; Offor, Collins; Oludotun, Taiwo G.; Tryland, Morten; Bøhn, Thomas; Moens, Ugo
Title: Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps? Document date: 2017_10_29
ID: 175igdfk_52
Snippet: The effect of deleting MVA genes in MVA-based vectors expressing foreign antigens on the immune response against these antigens has also been examined. Deletion of single or multiple MVA immunomodulatory genes stimulated the immune response against the foreign proteins expressed by the recombinant MVA mutant [170, 172, 173] . Alternatively, recombinant MVA vectors expressing host genes encoding immune stimulating proteins may trigger an increased.....
Document: The effect of deleting MVA genes in MVA-based vectors expressing foreign antigens on the immune response against these antigens has also been examined. Deletion of single or multiple MVA immunomodulatory genes stimulated the immune response against the foreign proteins expressed by the recombinant MVA mutant [170, 172, 173] . Alternatively, recombinant MVA vectors expressing host genes encoding immune stimulating proteins may trigger an increased immune response as was shown for MVA expressing granulocyte-macrophage colony-stimulating growth factor (GM-CSF) or C-C Motif Chemokine Ligand 20 (CCL20) in mice [174] . However, in rhesus macaques, high doses of GM-CSF expressed by MVA/GM-CSF inhibited mucosal antibody response and diminished protection elicited by MVA/Simian Immunodeficiency virus (SIV) macaque's vaccine [175] .
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