Gene Expression Profiling in Cells with Enhanced ?-Secretase Activity

Magold, Alexandra I.; Cacquevel, Matthias; Fraering, Patrick C.

Dataset S2 EST clones with decreased transcription under enhanced c-secretase compared to inhibited c-secretase activity. By applying a cut-off with a p value of 0.005 based on the false discovery rate (FDR, i.e. the probability to wrongly accept a difference between the two conditions), we found 2658 EST clones to be differentially expressed, with 1417 EST clones of decreased transcription with enhanced c-secretase activity compared to inhibited c-secretase activity. FC = Fold change; adj,P,Val = adjusted P-value Dataset S4 EST clones of transcriptional relevance differentially transcribed under enhanced c-secretase compared to inhibited csecretase activity. By applying a cut-off with a p value of 0.005 based on the false discovery rate (FDR, i.e. the probability to wrongly accept a difference between the two conditions), we found 2658 EST clones to be differentially expressed with enhanced c-secretase activity compared to inhibited c-secretase activity. Among them 56 imply transcriptional relevance. FC = Fold change; adj,P,Val = adjusted P-value. Found at: doi:10.1371/journal.pone.0006952.s004 (0.03 MB XLS)