Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects Document date: 2016_10_24
ID: 09tcnsxv_40
Snippet: The majority of all significantly regulated genes showed a unique pattern of regulation for each sample (Fig. 4a-c) . Looking more closely at the differences between astrocytes treated with supernatant or IFNαB/D, relatively few genes were downregulated, and we detected 257 genes upregulated in both samples, out of total 894 upregulated genes in the supernatant and 550 in IFNαB/D (Fig. 4b, c) . This indicated that although the main transcriptio.....
Document: The majority of all significantly regulated genes showed a unique pattern of regulation for each sample (Fig. 4a-c) . Looking more closely at the differences between astrocytes treated with supernatant or IFNαB/D, relatively few genes were downregulated, and we detected 257 genes upregulated in both samples, out of total 894 upregulated genes in the supernatant and 550 in IFNαB/D (Fig. 4b, c) . This indicated that although the main transcriptional response is type I IFN-dependent and overlaps with IFNαB/D treatment, virus infection induces numerous other IFN-independent responses in neighboring, uninfected astrocytes.
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