Selected article for: "rapid tbev infection IFN response and tbev infection IFN response"
Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects
  • Document date: 2016_10_24
    • ID: 09tcnsxv_54
    Snippet: Although IFNAR −/− astrocytes did induce ISGs at the mRNA level and viperin at the protein level, the kinetics were delayed compared to WT astrocytes indicating the importance of a rapid IFN response in order to control TBEV infection. To further characterize what makes the bystander cells resistant to flavivirus infection, astrocytes were treated with either inactivated supernatant from virus-infected cells or with IFNαB/D followed by RNAse.....
    Document: Although IFNAR −/− astrocytes did induce ISGs at the mRNA level and viperin at the protein level, the kinetics were delayed compared to WT astrocytes indicating the importance of a rapid IFN response in order to control TBEV infection. To further characterize what makes the bystander cells resistant to flavivirus infection, astrocytes were treated with either inactivated supernatant from virus-infected cells or with IFNαB/D followed by RNAseq. The RNAseq revealed that IFN signaling was the most upregulated pathway in supernatant-treated cells suggesting the IFN might be the most important signaling molecule produced by astrocytes upon TBEV infection. This is also true for other viruses, as increased expression of IFN signaling molecules and ISGs was observed in human astrocytes infected with Junin virus [52] .

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