Author: Brauburger, Kristina; Hume, Adam J.; Mühlberger, Elke; Olejnik, Judith
Title: Forty-Five Years of Marburg Virus Research Document date: 2012_10_1
ID: 0hlj6r10_82
Snippet: MARV infections usually occur by direct contact with infected body fluids or direct personal contact with infected animals or humans. The viruses enter the body through small skin lesions or mucosal membranes (reviewed in [47] ). Cells of the mononuclear phagocyte system, including monocytes, macrophages and dendritic cells, are early target cells of MARV, as shown in different experimental animal models [14, [192] [193] [194] [195] [196] [197] ......
Document: MARV infections usually occur by direct contact with infected body fluids or direct personal contact with infected animals or humans. The viruses enter the body through small skin lesions or mucosal membranes (reviewed in [47] ). Cells of the mononuclear phagocyte system, including monocytes, macrophages and dendritic cells, are early target cells of MARV, as shown in different experimental animal models [14, [192] [193] [194] [195] [196] [197] . MARV replication was observed as early as 24 hours post infection in macrophages of infected guinea pigs [63] , and infected monocytes have been found in cynomolgus macaques at 2 days post infection [193] . Monocytes and macrophages were also identified as early target cells in human patients [197] . This has been confirmed by cell culture experiments showing that primary human monocytes and macrophages are highly susceptible to MARV infection and produce infectious virus [198] [199] [200] . In addition, primary human monocyte-derived dendritic cells (mDCs) and endothelial cells support MARV replication [64, 146, 201] .
Search related documents:
Co phrase search for related documents- animal model and cell culture: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- animal model and cynomolgus macaque: 1, 2
- animal model and dendritic cell: 1, 2, 3
- animal model and direct contact: 1, 2, 3, 4, 5, 6, 7
- animal model and endothelial cell: 1, 2
- animal model and experimental animal model: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- animal model and guinea pig: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
- animal model and human infected animal: 1
- body enter and direct contact: 1
- body fluid and direct contact: 1, 2
- cell culture and dendritic cell: 1, 2, 3, 4, 5, 6, 7, 8
- cell culture and direct contact: 1, 2, 3, 4, 5, 6, 7, 8
- cell culture and endothelial cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- cell culture and experimental animal model: 1
- cell culture and guinea pig: 1, 2, 3, 4, 5
- cell culture and hour post: 1, 2
- cell culture and hour post infection: 1
- cynomolgus macaque and experimental animal model: 1
- dendritic cell and guinea pig: 1
Co phrase search for related documents, hyperlinks ordered by date