Author: Frenzel, André; Hust, Michael; Schirrmann, Thomas
Title: Expression of Recombinant Antibodies Document date: 2013_7_29
ID: 06o7pa3d_5
Snippet: For most therapeutic applications, the Fc moiety of an immunoglobulin is essential for the method of action as it mediates the effector functions such as cellular dependent cytotoxicity or the activation of the complement system. Therefore, antibody fragments have been fused to the Fc domain to regain effector functions and avidity (38, 39). Figure 1 depicts some of these antibody formats that have been developed for different applications......
Document: For most therapeutic applications, the Fc moiety of an immunoglobulin is essential for the method of action as it mediates the effector functions such as cellular dependent cytotoxicity or the activation of the complement system. Therefore, antibody fragments have been fused to the Fc domain to regain effector functions and avidity (38, 39). Figure 1 depicts some of these antibody formats that have been developed for different applications.
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