Assessing Topographic Structural Connectivity of the Human Basal Ganglia and Thalamus

Irtiza A. Gilani; Kader K. Oguz; Huseyin Boyaci; Katja Doerschner

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.06.981142 doi: bioRxiv preprint [Groenewegen and Berendse, 1994; Giménez-Amaya et al., 1995] . Connections from the medial thalamic nuclei to ventral striatal areas and the lateral thalamic nuclei to dorsal striatal areas were found in [Draganski et al., 2008] . Projections from thalamic CM/PF, medio-dorsal nucleus (MD), latero-polar nucleus (Lpo), ventro-oral anterior nucleus (Voa) and the dorso-intermediate nucleus [Draganski et al., 2008] . The central GPi's pallidal neurons that project to thalamic motor nuclei send axon collaterals to the caudal intralaminar nuclei [Parent et al. 1999] . Major associative inputs from the GPi end in the dorsolateral extension of PF (PFdl) thalamic region, which does not project back to CN but rather connects with the precommissural putamen. The limbic GPi is connected with the rostrodorsal part of PF, which projects back to the nucleus accumbens [Giménez-Amaya et al., 1995] . Ventral MD of Tha is STN [Lengelt et al., 2012] . We found similar projections, although the range of relative frequencies of connectivities is between significant and high. Rostral ventral anterior and MD nuclei project to both pallidum and dorsolateral prefrontal cortex [Draganski et al., 2008] . Ventral lateral Tha projects to pallidum; Pu and motor area; and premotor area [Draganski et al., 2008] . We found that the similar region of Tha has connections with Pu and BA 4 in the high relative frequency range and with GPe in the significant relative frequency range.