Selected article for: "data analysis and dose administration"
Author: Okeke, Malachy I.; Okoli, Arinze S.; Diaz, Diana; Offor, Collins; Oludotun, Taiwo G.; Tryland, Morten; Bøhn, Thomas; Moens, Ugo
Title: Hazard Characterization of Modified Vaccinia Virus Ankara Vector: What Are the Knowledge Gaps?
  • Document date: 2017_10_29
    • ID: 175igdfk_43
    Snippet: The environment is exposed to the virus vector/virus-vectored vaccine if it is shed by the vaccine recipient. In this case, hospital personnel, caregivers, non-vacinees and others may be exposed especially if the virus vector is shed via body fluids. When evaluating shedding, the biological properties of the virus vector/virus-vectored vaccine such as biodistribution, the status of the host including immunocompetence, dose and route of administra.....
    Document: The environment is exposed to the virus vector/virus-vectored vaccine if it is shed by the vaccine recipient. In this case, hospital personnel, caregivers, non-vacinees and others may be exposed especially if the virus vector is shed via body fluids. When evaluating shedding, the biological properties of the virus vector/virus-vectored vaccine such as biodistribution, the status of the host including immunocompetence, dose and route of administration, sampling frequency and duration of sampling, methods for sample analysis and data interpretation are important considerations. In addition, information on the biological properties of the wild-type strain can provide guidance in shedding evaluations.

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