Selected article for: "genome sequence and reading frame"
Author: Frey, Kenneth G.; Redden, Cassie L.; Bishop-Lilly, Kimberly A.; Johnson, Reed; Hensley, Lisa E.; Raviprakash, Kanakatte; Luke, Thomas; Kochel, Tad; Mokashi, Vishwesh P.; Defang, Gabriel N.
Title: Full-Genome Sequence of Human Betacoronavirus 2c Jordan-N3/2012 after Serial Passage in Mammalian Cells
  • Document date: 2014_5_29
    • ID: 0b2blj2c_2
    Snippet: It has been reported that MERS-CoV is capable of replicating in a wide variety of mammalian cell types (7) . However, it was unclear if serial growth impacts the viral genome. Here, we report the whole-genome sequence of MERS-CoV Jordan-N3/2012 after sequential passage in Vero CCL81 cells and a human embryonic fibroblast line (MRC5). The genome of MERS-CoV is a singlestranded RNA (ssRNA) encoding 10 proteins: a replicase polyprotein, (ORF1ab), th.....
    Document: It has been reported that MERS-CoV is capable of replicating in a wide variety of mammalian cell types (7) . However, it was unclear if serial growth impacts the viral genome. Here, we report the whole-genome sequence of MERS-CoV Jordan-N3/2012 after sequential passage in Vero CCL81 cells and a human embryonic fibroblast line (MRC5). The genome of MERS-CoV is a singlestranded RNA (ssRNA) encoding 10 proteins: a replicase polyprotein, (ORF1ab), three structural proteins (E, N, and M), a surface glycoprotein (S), and five nonstructural proteins (open reading frame [ORF] 3, 4a, 4b, 5, and 8b) (2).

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