Author: Cong, Wei; Zhang, Xiao-Xuan; He, Jun-Jun; Li, Fa-Cai; Elsheikha, Hany M.; Zhu, Xing-Quan
Title: Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection Document date: 2017_3_10
ID: 05tshufp_17
Snippet: The let-7 family is a key regulator of the innate immune response. The level of let-7i during protozoal infection with C. parvum infection was found reduced together with increase of TLR4 in biliary epithelial cells, contributing to cholangiocyte's defense responses [46] . In line with this study our results revealed significant downregulation of mmu-let-7f-5p, mmu-let-7i-5p, mmulet-7a-5p, mmu-let-7g-5p, mmu-let-7e-5p, and mmu-let-7c-5p in T. gon.....
Document: The let-7 family is a key regulator of the innate immune response. The level of let-7i during protozoal infection with C. parvum infection was found reduced together with increase of TLR4 in biliary epithelial cells, contributing to cholangiocyte's defense responses [46] . In line with this study our results revealed significant downregulation of mmu-let-7f-5p, mmu-let-7i-5p, mmulet-7a-5p, mmu-let-7g-5p, mmu-let-7e-5p, and mmu-let-7c-5p in T. gondii-infected cat's livers compared with controls. Finally, the fact that miRNAs are host-, tissue-, and strain-specific [47] explains why the expression of some miRNA (e.g. miR-712-3p, miR-511-5p and miR-217-5p) that are dysregulated during T. gondii infection [48] was not altered in our study.
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