Author: Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; Wölfel, Silke; Gekara, Nelson O.; Kröger, Andrea; Överby, Anna K.
Title: Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects Document date: 2016_10_24
ID: 09tcnsxv_57
Snippet: Previous studies have revealed that although TBEV infects astrocytes, viral infection did not affect the viability of the cells [34, 35] . Similar findings have been observed with other viral infections such as WNV, JEV, and Junin virus whereas infection with Venezuelan equine encephalitis virus infection induced cell death in cultured astrocytes [31, 37, 39, 85, 86] . However, the mechanism underlying the resistance to virus-induced cell death i.....
Document: Previous studies have revealed that although TBEV infects astrocytes, viral infection did not affect the viability of the cells [34, 35] . Similar findings have been observed with other viral infections such as WNV, JEV, and Junin virus whereas infection with Venezuelan equine encephalitis virus infection induced cell death in cultured astrocytes [31, 37, 39, 85, 86] . However, the mechanism underlying the resistance to virus-induced cell death in astrocytes is not well understood. Here, we show that the type I IFN response prevents TBEV-mediated cytopathic effect. Blocking of IFNAR using antibodies as well as IFNAR knockout induced TBEV-mediated cell death of astrocytes whereas the WT control remained unaffected.
Search related documents:
Co phrase search for related documents- cell death and equine encephalitis: 1, 2
- cell death and equine encephalitis virus: 1, 2
- cell death and ifn response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- cell death and Junin virus: 1
- cell death and previous study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20
- cell death and unaffected remain: 1
- cell death and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- cell death and virus induce: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- cell death and virus induce cell death: 1, 2, 3
- cell death induce and cytopathic effect: 1, 2
- cell death induce and previous study: 1
- cell death induce and viral infection: 1, 2, 3, 4, 5, 6, 7, 8
- cell death induce and virus induce: 1, 2, 3
- cell death induce and virus induce cell death: 1, 2, 3
- cell viability and cytopathic effect: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
- cell viability and equine encephalitis: 1
- cell viability and equine encephalitis virus: 1
- cell viability and ifn response: 1, 2
- cell viability and previous study: 1, 2, 3, 4, 5, 6, 7
Co phrase search for related documents, hyperlinks ordered by date