Author: Vidaña, Beatriz; Martínez, Jorge; Martínez-Orellana, Pamela; García Migura, Lourdes; Montoya, María; Martorell, Jaime; Majó, Natàlia
Title: Heterogeneous pathological outcomes after experimental pH1N1 influenza infection in ferrets correlate with viral replication and host immune responses in the lung Document date: 2014_8_28
ID: 0hyg403m_5
Snippet: This study attempted to clarify whether the variance in virulence of pH1N1 isolates in humans significantly correlates with the clinicopathological outcome in an animal model of influenza infection. The aim of this study was accomplished by experimentally infecting ferrets with two pH1N1 isolates from two human patients who developed different clinical outcomes. The viral dynamics and host immune responses of the lungs of the infected ferrets wer.....
Document: This study attempted to clarify whether the variance in virulence of pH1N1 isolates in humans significantly correlates with the clinicopathological outcome in an animal model of influenza infection. The aim of this study was accomplished by experimentally infecting ferrets with two pH1N1 isolates from two human patients who developed different clinical outcomes. The viral dynamics and host immune responses of the lungs of the infected ferrets were thoroughly investigated. Assessments of the pathologic patterns of the lungs and measurements of immune cell and cytokine responses and apoptotic cell induction were performed to identify the factors involved in the outcome of this disease.
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