Author: Bloom, Kristie; Maepa, Mohube Betty; Ely, Abdullah; Arbuthnot, Patrick
Title: Gene Therapy for Chronic HBV—Can We Eliminate cccDNA? Document date: 2018_4_12
ID: 0dr9eans_23
Snippet: Realization of a functional or complete cure for chronic HBV infections requires innovative therapeutic approaches aimed at disabling and eliminating the persistent episomal cccDNA. Drugs that act directly on the viral genome, such as designer nucleases and epigenetic modifiers, have the potential to disable viral replication permanently. Restoration of the anti-HBV immune response may also facilitate clearance of infected hepatocytes and thus di.....
Document: Realization of a functional or complete cure for chronic HBV infections requires innovative therapeutic approaches aimed at disabling and eliminating the persistent episomal cccDNA. Drugs that act directly on the viral genome, such as designer nucleases and epigenetic modifiers, have the potential to disable viral replication permanently. Restoration of the anti-HBV immune response may also facilitate clearance of infected hepatocytes and thus diminish or eradicate the cccDNA pool. A combination of gene-based immune and cccDNA-targeting gene therapy may provide the means to achieve this goal.
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