Selected article for: "µg ml and anti effect"
Author: Huang, Nan-Chieh; Hung, Wan-Ting; Tsai, Wei-Lun; Lai, Feng-Yi; Lin, You-Sheng; Huang, Mei-Shu; Chen, Jih-Jung; Lin, Wei-Yu; Weng, Jing-Ru; Chang, Tsung-Hsien
Title: Ficus septica plant extracts for treating Dengue virus in vitro
  • Document date: 2017_6_8
    • ID: 1a3cmi9i_18
    Snippet: In addition to DENV-2, the DENV-1 was inhibited by FS-(L)-M in A549 cells (IC 50 = 28 ± 10.4 µg/ml); however, the AiV infection was not affected by FS-(L)-M treatment (Figs. 1A and 1B) . DENV infection-mediated liver disorder was reported (Samanta & Sharma, 2015; Tristao-Sa et al., 2012) , therefore, the F. septica against DENV1 and DENV-2 but not AiV were also confirmed in the hematoma cell lines, HepG2 and Huh7.5 cells (Figs. 1C and 1E). Inte.....
    Document: In addition to DENV-2, the DENV-1 was inhibited by FS-(L)-M in A549 cells (IC 50 = 28 ± 10.4 µg/ml); however, the AiV infection was not affected by FS-(L)-M treatment (Figs. 1A and 1B) . DENV infection-mediated liver disorder was reported (Samanta & Sharma, 2015; Tristao-Sa et al., 2012) , therefore, the F. septica against DENV1 and DENV-2 but not AiV were also confirmed in the hematoma cell lines, HepG2 and Huh7.5 cells (Figs. 1C and 1E). Interestingly, FS-(L)-M showed more potent anti-DENV-1 and DENV-2 effect in HepG2 cells (IC 50 = 10.1 ± 2.4 µg/ml and 12.2 ± 2.1 µg/ml, respectively) then in Huh7.5 cells (IC 50 = 39.8 ± 6.9 µg/ml and 21.9 ± 3.9 µg/ml, respectively) (Figs. 1D and 1F). Moreover, skin normal fibroblasts (Wang et al., 2015) , WS1 cells were used as the non-cancerous cells for testing the anti-viral effect of FS-(L)-M. The similar results showed that the FS-(L)-M inhibited DENV-1 and DENV-2 in WS1 cells with IC 50 13.3±2.6 µg/ml and 10.6±1.1 µg/ml, respectively (Figs. 1G and 1H). A higher dose of F. septica (IC 50 41.1 ± 6.7 µg/ml) against AiV was determined in WS1 cells, which was not showed in other tested cells types. This data implicated a cell type-specific manner of AiV inhibition by F. septica. However, the precise mechanism remains to be further explored.

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