Author: Vidaña, Beatriz; Martínez, Jorge; Martínez-Orellana, Pamela; García Migura, Lourdes; Montoya, María; Martorell, Jaime; Majó, Natàlia
Title: Heterogeneous pathological outcomes after experimental pH1N1 influenza infection in ferrets correlate with viral replication and host immune responses in the lung Document date: 2014_8_28
ID: 0hyg403m_47
Snippet: The apoptotic genes BAX and CASP8 in the lungs of the infected animals were analysed with RT-qPCR. The gene expressions of BAX and CASP8 were elevated in both infected groups compared to the control group (data not shown). However, comparison of the apoptotic induction in the lungs of the animals that presented with different grades of lung pathology revealed that the animals with severe lung lesions exhibited elevations in the inductions of both.....
Document: The apoptotic genes BAX and CASP8 in the lungs of the infected animals were analysed with RT-qPCR. The gene expressions of BAX and CASP8 were elevated in both infected groups compared to the control group (data not shown). However, comparison of the apoptotic induction in the lungs of the animals that presented with different grades of lung pathology revealed that the animals with severe lung lesions exhibited elevations in the inductions of both apoptotic markers compared to the animals with mild lung lesions at both 4 and 7 dpi ( Figure 6A ).
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