Author: Zheng, Yueming; Zhu, Xuejing; Zhou, Pingzheng; Lan, Xi; Xu, Haiyan; Li, Min; Gao, Zhaobing
Title: Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants Document date: 2012_12_12
ID: 1manzf3l_24
Snippet: HCP, also known as Nabac, is the active component of pHisoHex, a prescription drug widely used as an effective antibacterial skin cleanser in the treatment of acne [17] . In previous studies, HCP has been identified as an inhibitor of enoylacyl carrier protein reductase and 3CL protease of SARS-CoV [22, 23] . It was also found to attenuate Wnt/b-catenin signaling pathway, which plays important roles in cell proliferation, differentiation and onco.....
Document: HCP, also known as Nabac, is the active component of pHisoHex, a prescription drug widely used as an effective antibacterial skin cleanser in the treatment of acne [17] . In previous studies, HCP has been identified as an inhibitor of enoylacyl carrier protein reductase and 3CL protease of SARS-CoV [22, 23] . It was also found to attenuate Wnt/b-catenin signaling pathway, which plays important roles in cell proliferation, differentiation and oncogenesis [24] . In the current study, we identified HCP as an activator of KCNQ channels.
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