Selected article for: "active component and KCNQ1 KCNE1 activator"
Author: Zheng, Yueming; Zhu, Xuejing; Zhou, Pingzheng; Lan, Xi; Xu, Haiyan; Li, Min; Gao, Zhaobing
Title: Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants
  • Document date: 2012_12_12
    • ID: 1manzf3l_4
    Snippet: We screened a collection of 1,280 drugs or drug candidates against homomeric KCNQ channels and identified HCP as one of active compounds. HCP, also known as Nabac, is the active component of pHisoHex, a topical anti-infective prescription drug [17] . We found that both the homomeric KCNQ1 and the KCNQ1/KCNE1 complex were sensitive to HCP at micromolar concentrations and the effect on the KCNQ1/KCNE1 complex is much more potent than that on homome.....
    Document: We screened a collection of 1,280 drugs or drug candidates against homomeric KCNQ channels and identified HCP as one of active compounds. HCP, also known as Nabac, is the active component of pHisoHex, a topical anti-infective prescription drug [17] . We found that both the homomeric KCNQ1 and the KCNQ1/KCNE1 complex were sensitive to HCP at micromolar concentrations and the effect on the KCNQ1/KCNE1 complex is much more potent than that on homomeric KCNQ1. Further studies showed that HCP was effective in cardiomyocytes and was capable of rescuing the LQTs KCNQ1 mutants. Taken together, our study indicates that HCP as an effective KCNQ1/KCNE1 activator.

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