Author: Franzo, Giovanni; Cecchinato, Mattia; Tosi, Giovanni; Fiorentini, Laura; Faccin, Francesca; Tucciarone, Claudia Maria; Trogu, Tiziana; Barbieri, Ilaria; Massi, Paola; Moreno, Ana
Title: GI-16 lineage (624/I or Q1), there and back again: The history of one of the major threats for poultry farming of our era Document date: 2018_12_20
ID: 0pi042qi_26
Snippet: Understandably, other factors could have played a role, like within-country viral evolution leading to the emergence of virulent strain, more fit for the Italian context. To investigate this issue, an ancestral state reconstruction of the amino-acid profile variation over time was performed using a Maximum-likelihood approach (S3 Fig). Albeit some amino-acid changes were detected in the clade including contemporary Italian strains, no distinctive.....
Document: Understandably, other factors could have played a role, like within-country viral evolution leading to the emergence of virulent strain, more fit for the Italian context. To investigate this issue, an ancestral state reconstruction of the amino-acid profile variation over time was performed using a Maximum-likelihood approach (S3 Fig). Albeit some amino-acid changes were detected in the clade including contemporary Italian strains, no distinctive mutations differentiating this group from their ancestors were identified, at least in the considered region. While the "local evolution" hypothesis appears lessened by this evidence, further studies will be necessary to investigate the potential role of other S1/genomic regions.
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