Frequent Respiratory Viral Infections in Children with Febrile Neutropenia - A Prospective Follow-Up Study

Söderman, Martina; Rhedin, Samuel; Tolfvenstam, Thomas; Rotzén-Östlund, Maria; Albert, Jan; Broliden, Kristina; Lindblom, Anna

Days with antibiotics (n = 1, 1%) ( Table 2 ). In 12 of the virus-positive episodes, the patient was <4 years of age. The most common respiratory virus identified in the group <4 years of age was RV (n = 9), followed by PIV (n = 2), HCoV (n = 2), HAdV (n = 1), HBoV (n = 1) and RSV (n = 1). In addition, one episode with co-presence with a respiratory virus and septicemia was identified in the group <4 years of age. Of the 36 episodes involving only respiratory viral infection (i.e., infection with either a single respiratory virus or multiple respiratory viruses) respiratory symptoms were detected in 31 (86%) ( Table 1) . No symptoms were apparent in four episodes involving RV and one episode involving HCoV (Table 2) . Of the 31 episodes involving respiratory symptoms, 26 reported the appearance of respiratory symptoms at time of fever onset ( Table 2 ). In the remaining five episodes, the respiratory symptoms appeared over 6 days before the onset of fever. These five episodes represented one Flu B and four RV ( Table 2 ).