Author: Marcotullio, Maria Carla; Pelosi, Azzurra; Curini, Massimo
Title: Hinokinin, an Emerging Bioactive Lignan Document date: 2014_9_17
ID: 04kh4yzy_12
Snippet: Recently Awale et al. studied the cytotoxicity of several lignans isolated from W. indica, against Panc-1 cancer cell line (human pancreatic cancer) [74] . They found that (8S,8′S)-(+)-hinokinin as well as other lignans, such as (+)-arctigenin, with the same stereochemistry, were inactive against Panc-1 cell line, whereas the (−) enantiomers were cytotoxic. These results indicate that the absolute configuration of (−)-enantiomers is require.....
Document: Recently Awale et al. studied the cytotoxicity of several lignans isolated from W. indica, against Panc-1 cancer cell line (human pancreatic cancer) [74] . They found that (8S,8′S)-(+)-hinokinin as well as other lignans, such as (+)-arctigenin, with the same stereochemistry, were inactive against Panc-1 cell line, whereas the (−) enantiomers were cytotoxic. These results indicate that the absolute configuration of (−)-enantiomers is required for the cytotoxicity. Hinokinin resulted ineffective against HONE-1 (nasopharyngeal carcinoma) and UGC-3 (gastric adenocarcinoma) cell lines [75] .
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