Author: Schildgen, Oliver
Title: Human Bocavirus: Lessons Learned to Date Document date: 2013_1_11
ID: 1qyuhbz0_11
Snippet: Overexpressed VP2 protein is able to form capsid-like structures that strongly resemble viral particles [20] . VP2 particles were used to analyze Th cell immunity by evaluating HBoV-specific T-cell proliferation in T-cells isolated from healthy adults [21] . In contrast to parvovirus B19, HBoV induces a less divergent Th response with respect to proliferation and interferon gamma, IL10 and IL13 production. The NP1 protein was shown to have immuno.....
Document: Overexpressed VP2 protein is able to form capsid-like structures that strongly resemble viral particles [20] . VP2 particles were used to analyze Th cell immunity by evaluating HBoV-specific T-cell proliferation in T-cells isolated from healthy adults [21] . In contrast to parvovirus B19, HBoV induces a less divergent Th response with respect to proliferation and interferon gamma, IL10 and IL13 production. The NP1 protein was shown to have immunomodulatory effects; using a cell culture approach with a nearly full-length clone of HBoV, Zhang and colleagues have shown that NP1 is able to indirectly block the IFN-β promoter and thus inhibit the production of interferon beta [22].
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