Author: Schildgen, Oliver
Title: Human Bocavirus: Lessons Learned to Date Document date: 2013_1_11
ID: 1qyuhbz0_7
Snippet: To date, the genome replication of HBoV has been assumed to occur in the same manner as the genome replication of animal parvovirus, that is, via a rolling hairpin mechanism, which would generate head-to-head or tail-to-tail intermediates, but the recently detected head-to-tail sequences do not fit with this replication model [7, 8] . A novel cell culture system based on NuLi and CuFi cells, immortalized cell lines with the ability to differentia.....
Document: To date, the genome replication of HBoV has been assumed to occur in the same manner as the genome replication of animal parvovirus, that is, via a rolling hairpin mechanism, which would generate head-to-head or tail-to-tail intermediates, but the recently detected head-to-tail sequences do not fit with this replication model [7, 8] . A novel cell culture system based on NuLi and CuFi cells, immortalized cell lines with the ability to differentiate in an air-liquid interface culture, could be appropriate models in which to study the questions regarding HBoV replication [13] . This recently published cell culture model is able to support HBoV replication and produce classical replication forms for parvoviruses; moreover, it was shown that the full-length HBoV-1 genome cloned into a plasmid vector was able to produce infectious particles in stable cells after transfection of the plasmid [13] .
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