Gaining Insights into the Codon Usage Patterns of TP53 Gene across Eight Mammalian Species

Mazumder, Tarikul Huda; Chakraborty, Supriyo

The ENC values of the coding sequences ranged from 52 to 59 with a mean of 55.5±2.33 indicating relatively smaller variation in the codon usage of TP53 gene across eight mammalian species. However, the GC 3s values ranged from 0.59 to 0.71 with a mean value of 0.65±0.040. Significant negative correlation (Pearson r = -0.979, p<0.01) was observed between ENC and GC 3s . Moreover, a plot of ENC vs GC 3s revealed that the ENC values had negative correlation with the GC 3 content (Fig. 5 ) and comparatively lower ENC was linked to higher GC 3s values. All the selected coding sequences of TP53 gene across the selected mammalian species had Overall frequency of optimal and non optimal codon used in TP53 genes among mammals. Red color coding represents optimal used codons with corresponding amino acid.