Author: Bloom, Kristie; Maepa, Mohube Betty; Ely, Abdullah; Arbuthnot, Patrick
Title: Gene Therapy for Chronic HBV—Can We Eliminate cccDNA? Document date: 2018_4_12
ID: 0dr9eans_21
Snippet: Reconstituting the cytotoxic T-cell response against HBV holds great promise as a strategy for the immune-mediated clearance of the virus in chronic carriers. While engineered T-cells with chimeric T-cell receptors against HBV antigens have been developed, investigations are yet to progress beyond preclinical development of the technology [101] [102] [103] [104] [105] . DNA vaccines have the potential to induce strong antibody and T-cell-mediated.....
Document: Reconstituting the cytotoxic T-cell response against HBV holds great promise as a strategy for the immune-mediated clearance of the virus in chronic carriers. While engineered T-cells with chimeric T-cell receptors against HBV antigens have been developed, investigations are yet to progress beyond preclinical development of the technology [101] [102] [103] [104] [105] . DNA vaccines have the potential to induce strong antibody and T-cell-mediated immune responses and thereby clear chronic HBV infections (reviewed by [106] ). While studies exploring this strategy are few, inducing strong antiviral immunity with therapeutic vaccines in conjunction with cytokine-mediated stimulation of an immune response undoubtedly has potential for management of chronic hepatitis B.
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