Selected article for: "active component and KCNQ channel"
Author: Zheng, Yueming; Zhu, Xuejing; Zhou, Pingzheng; Lan, Xi; Xu, Haiyan; Li, Min; Gao, Zhaobing
Title: Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants
  • Document date: 2012_12_12
    • ID: 1manzf3l_31
    Snippet: In conclusion, we identified HCP, the active component of a prescription drug, as a potent KCNQ channel activator with unique subtype selectivity. It exhibits strong potentiation effects on both the homomeric KCNQ1 and the KCNQ1/KCNE1 complex. The distinct pharmacological phenotype and chemical structure of HCP from other reported activators suggest that HCP represents a novel class of KCNQ1/KCNE1 activators. The activity of shortening the action.....
    Document: In conclusion, we identified HCP, the active component of a prescription drug, as a potent KCNQ channel activator with unique subtype selectivity. It exhibits strong potentiation effects on both the homomeric KCNQ1 and the KCNQ1/KCNE1 complex. The distinct pharmacological phenotype and chemical structure of HCP from other reported activators suggest that HCP represents a novel class of KCNQ1/KCNE1 activators. The activity of shortening the action potential duration and the ability to rescuing the loss-of-function of LQTs mutants make HCP a useful tool in development of therapeutics for LQTs.

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