High Pulmonary Levels of IL-6 and IL-1ß in Children with Chronic Suppurative Lung Disease Are Associated with Low Systemic IFN-? Production in Response to Non-Typeable Haemophilus influenzae

Pizzutto, Susan J.; Upham, John W.; Yerkovich, Stephanie T.; Chang, Anne B.

Data were analysed using the statistics package STATA 13 (StataCorp, USA). As the data did not follow a normal distribution, group data was described as median with interquartile range (IQR). Differences between groups were assessed using the Mann-Whitney U test. A two-tailed p-value 0.05 was considered significant. Univariate regression analysis was used to assess the potential of systemic and airway inflammatory markers and clinical factors to predict in vitro NTHi-specific IFN-γ production. NTHi-specific IFN-γ concentration was natural log transformed prior to regression analysis. Variables with a p value <0.1 were included in a multivariate regression model. Within this multivariate model, a p value of <0.05 was considered an independent predictor of the capacity to produce IFN-γ in vitro in response to NTHi.