Selected article for: "airway disease and univariate analysis"
Author: Pizzutto, Susan J.; Upham, John W.; Yerkovich, Stephanie T.; Chang, Anne B.
Title: High Pulmonary Levels of IL-6 and IL-1ß in Children with Chronic Suppurative Lung Disease Are Associated with Low Systemic IFN-? Production in Response to Non-Typeable Haemophilus influenzae
  • Document date: 2015_6_12
    • ID: 19jo817j_29
    Snippet: Indications of airway inflammation include changes in cellular profile and the presence of pro-inflammatory cytokines in the BAL or sputum. In adults and children with suppurative lung disease, airway inflammation is characterised by elevated levels of neutrophils, IL-1β, IL-6 and IL-8 [11, 19, 20] . Thus, we chose to focus on these cytokines. We found that, in our cohort of young children with CSLD, IL-1β, IL-6, IL-8 as well as IP-10 and LL-37.....
    Document: Indications of airway inflammation include changes in cellular profile and the presence of pro-inflammatory cytokines in the BAL or sputum. In adults and children with suppurative lung disease, airway inflammation is characterised by elevated levels of neutrophils, IL-1β, IL-6 and IL-8 [11, 19, 20] . Thus, we chose to focus on these cytokines. We found that, in our cohort of young children with CSLD, IL-1β, IL-6, IL-8 as well as IP-10 and LL-37 in the BAL were significantly correlated with BAL neutrophils. These markers of inflammation also negatively correlated with systemic NTHi-specific IFN-γ production on univariate analysis. However, on multivariate regression, only IL-6 and IL-1β were significantly and independently associated with NTHi-specific IFN-γ production.

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