Author: Tang, Fang; Liu, Wei; Zhang, Fang; Xin, Zhong-Tao; Wei, Mao-Ti; Zhang, Pan-He; Yang, Hong; Ly, Hinh; Cao, Wu-Chun
Title: IL-12 RB1 Genetic Variants Contribute to Human Susceptibility to Severe Acute Respiratory Syndrome Infection among Chinese Document date: 2008_5_14
ID: 01o15wd4_14
Snippet: Association between genotype frequencies of the 4 SNPs and the severity of SARS SARS patients were then divided into two subgroups according to the severity of the disease: advanced subgroup (i.e., patients with moderate or advanced lung disease) and mild subgroup. Multiple regression models were re-established for each SNP, with age, sex and the source of infection hospital as covariates. Association with the severity of SARS infection was then .....
Document: Association between genotype frequencies of the 4 SNPs and the severity of SARS SARS patients were then divided into two subgroups according to the severity of the disease: advanced subgroup (i.e., patients with moderate or advanced lung disease) and mild subgroup. Multiple regression models were re-established for each SNP, with age, sex and the source of infection hospital as covariates. Association with the severity of SARS infection was then estimated by comparing the genotype frequencies and allele frequencies of all the SNPs between the two groups of SARS patients. The final model building disclosed prominent associations between advanced disease with carrying +1664 C/T (CT) and (TT) genotype (P = 0.037). However, this was found not to be significant after Nyholt correction was applied to the analysis. Again, there were no significant differences in the genotype and allele distributions of the +705 A/G , +1158T/C or +1196 G/C SNPs between those with mild disease and those with advanced disease (data not shown).
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