Selected article for: "chromosome gene and family gene"
Author: Bekpen, Cemalettin; Tautz, Diethard
Title: Human core duplicon gene families: game changers or game players?
  • Document date: 2019_9_16
    • ID: 0fjh10v7_14
    Snippet: RGPD genes (RanBP2-like, GRIP domain-containing Proteins) are derived from the RANBP2 gene. RANBP2 (NUP388) is a Ranbinding protein that was shown to interact with the nuclear pore complex. The RGPD gene family has expanded to eight dispersed copies on human chromosome 2 through segmental duplication [15] . Similar to other core duplicon gene families, RGPD genes are rapidly evolving. Different exons of RGPD genes were shown to evolve under posit.....
    Document: RGPD genes (RanBP2-like, GRIP domain-containing Proteins) are derived from the RANBP2 gene. RANBP2 (NUP388) is a Ranbinding protein that was shown to interact with the nuclear pore complex. The RGPD gene family has expanded to eight dispersed copies on human chromosome 2 through segmental duplication [15] . Similar to other core duplicon gene families, RGPD genes are rapidly evolving. Different exons of RGPD genes were shown to evolve under positive selection [15] . The macaque genome, as well as the mouse and other mammalian genomes, does not contain duplicates, suggesting that expansion occurred within the great apes after the separation from old world monkeys.

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