Author: Vidaña, Beatriz; Martínez, Jorge; Martínez-Orellana, Pamela; García Migura, Lourdes; Montoya, María; Martorell, Jaime; Majó, Natàlia
Title: Heterogeneous pathological outcomes after experimental pH1N1 influenza infection in ferrets correlate with viral replication and host immune responses in the lung Document date: 2014_8_28
ID: 0hyg403m_61
Snippet: This study represents an exhaustive characterisation of the inflammatory cell populations and proinflammatory gene expression profiles in the lungs of pH1N1-infected ferrets. Additionally, despite the limited number of animals used, we provided further evidence regarding the implications of viral replication efficiency, inflammatory cytokine induction, and phagocytic and cytotoxic cell infiltration in influenza-infected lungs that are associated .....
Document: This study represents an exhaustive characterisation of the inflammatory cell populations and proinflammatory gene expression profiles in the lungs of pH1N1-infected ferrets. Additionally, despite the limited number of animals used, we provided further evidence regarding the implications of viral replication efficiency, inflammatory cytokine induction, and phagocytic and cytotoxic cell infiltration in influenza-infected lungs that are associated with pathology at the time of the switch from the innate to the adaptive immune response. More importantly, our results support the notion that viral replication and the correct orchestration of the early inflammatory response are key factors in the development of severe influenza.
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