Author: Marcotullio, Maria Carla; Pelosi, Azzurra; Curini, Massimo
Title: Hinokinin, an Emerging Bioactive Lignan Document date: 2014_9_17
ID: 04kh4yzy_20
Snippet: The antitrypanosomal activity of hinokinin was determined using the MTT assay by Sartorelli and coworkers [90] . They evaluated 1 against trypomastigotes and intracellular amastigotes of T. cruzi. Results are shown in Table 3 . In order to study the toxicity of hinokinin (1) in mammalian cells, Sartorelli also studied hinokinin's hemolytic activity and cytotoxicity. Hinokinin was shown to be effective on trypomastigotes, but it resulted toxic to .....
Document: The antitrypanosomal activity of hinokinin was determined using the MTT assay by Sartorelli and coworkers [90] . They evaluated 1 against trypomastigotes and intracellular amastigotes of T. cruzi. Results are shown in Table 3 . In order to study the toxicity of hinokinin (1) in mammalian cells, Sartorelli also studied hinokinin's hemolytic activity and cytotoxicity. Hinokinin was shown to be effective on trypomastigotes, but it resulted toxic to mammalian cells and with a low parasite selectivity (selectivity index <1) [90] .
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