Author: Marcotullio, Maria Carla; Pelosi, Azzurra; Curini, Massimo
Title: Hinokinin, an Emerging Bioactive Lignan Document date: 2014_9_17
ID: 04kh4yzy_39
Snippet: Methylenedioxyphenyl compounds were well known to inhibit cytochrome P (CYP) reaction because they form stable complexes with CYP enzymes [107] . For this reason, several natural compounds incorporating this structural feature have been studied for their inhibitory activity of CYP enzymes. Hinokinin (1) containing two methylenedioxyphenyl rings in the molecules, showed potent CYP inhibition [108] . Later Usia et al. showed that hinokinin is activ.....
Document: Methylenedioxyphenyl compounds were well known to inhibit cytochrome P (CYP) reaction because they form stable complexes with CYP enzymes [107] . For this reason, several natural compounds incorporating this structural feature have been studied for their inhibitory activity of CYP enzymes. Hinokinin (1) containing two methylenedioxyphenyl rings in the molecules, showed potent CYP inhibition [108] . Later Usia et al. showed that hinokinin is active on CYP3A4 but not on CYP2D6 [109] and that CYP3A4 is inhibited in a time-, concentration-and NADPH-dependent manners via the formation of a metabolite intermediate complex [110] , therefore, attention should be paid to a probable drug-drug interaction between hinokinin-containing preparations and molecules that are substrates of CYP3A4.
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