Selected article for: "acute gondii infection and hepatic miRNAs expression"
Author: Cong, Wei; Zhang, Xiao-Xuan; He, Jun-Jun; Li, Fa-Cai; Elsheikha, Hany M.; Zhu, Xing-Quan
Title: Global miRNA expression profiling of domestic cat livers following acute Toxoplasma gondii infection
  • Document date: 2017_3_10
    • ID: 05tshufp_4
    Snippet: In this study, we hypothesized that T. gondii infection alters the expression of hepatic miRNAs and that differentially expressed miRNAs mediate the interaction between T. gondii and cat's liver. Here we use genomewide, small RNA sequencing to characterize the global miRNA transcriptional response of feline liver to infection with T. gondii (Type II) PRU strain. Our study provides a full picture of the hepatic miRNA repertoire during acute T. gon.....
    Document: In this study, we hypothesized that T. gondii infection alters the expression of hepatic miRNAs and that differentially expressed miRNAs mediate the interaction between T. gondii and cat's liver. Here we use genomewide, small RNA sequencing to characterize the global miRNA transcriptional response of feline liver to infection with T. gondii (Type II) PRU strain. Our study provides a full picture of the hepatic miRNA repertoire during acute T. gondii infection in domestic cats, including novel miRNAs, involved in host cell cycle, apoptosis and anti-T. gondii defense.

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