Author: Wang, Ran; Moniruzzaman, Md.; Shuffle, Eric; Lourie, Rohan; Hasnain, Sumaira Z
Title: Immune regulation of the unfolded protein response at the mucosal barrier in viral infection Document date: 2018_4_3
ID: 07dlf3zw_31
Snippet: The impact of cytokines on oxidative stress and the UPR can dictate protein biosynthesis. For example, type I interferon signalling has been shown to regulate chronic hepatitis B virus infection via induction of oxidative stress in epithelial cells. [71] [72] [73] [74] Anti-viral effects of other cytokines such as TNF-a have also been shown to induce apoptotic pathways in infected cells. Our work shows that specific cytokines (IL-17, IL-23) local.....
Document: The impact of cytokines on oxidative stress and the UPR can dictate protein biosynthesis. For example, type I interferon signalling has been shown to regulate chronic hepatitis B virus infection via induction of oxidative stress in epithelial cells. [71] [72] [73] [74] Anti-viral effects of other cytokines such as TNF-a have also been shown to induce apoptotic pathways in infected cells. Our work shows that specific cytokines (IL-17, IL-23) locally cause ER stress, particularly in cells with an inherent susceptibility to protein misfolding or inadequate UPR.
Search related documents:
Co phrase search for related documents- anti viral effect and infected cell: 1
- anti viral effect and interferon signalling: 1
- anti viral effect and oxidative stress: 1
- anti viral effect and protein biosynthesis: 1
- anti viral effect and specific cytokine: 1
- apoptotic pathway and epithelial cell: 1, 2, 3
- apoptotic pathway and ER stress: 1, 2, 3, 4, 5, 6, 7
- apoptotic pathway and infected cell: 1, 2, 3, 4, 5
- apoptotic pathway and infected cell apoptotic pathway: 1
- apoptotic pathway and oxidative stress: 1, 2, 3
- epithelial cell and ER stress: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- epithelial cell and infected cell: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- epithelial cell and interferon signalling: 1
- epithelial cell and oxidative stress: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24
- epithelial cell and oxidative stress cytokine: 1, 2
- epithelial cell and oxidative stress induction: 1
- epithelial cell and protein biosynthesis: 1
- epithelial cell and protein misfolding: 1
- epithelial cell and specific cytokine: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date