Author: Wang, Ran; Moniruzzaman, Md.; Shuffle, Eric; Lourie, Rohan; Hasnain, Sumaira Z
Title: Immune regulation of the unfolded protein response at the mucosal barrier in viral infection Document date: 2018_4_3
ID: 07dlf3zw_31
Snippet: The impact of cytokines on oxidative stress and the UPR can dictate protein biosynthesis. For example, type I interferon signalling has been shown to regulate chronic hepatitis B virus infection via induction of oxidative stress in epithelial cells. [71] [72] [73] [74] Anti-viral effects of other cytokines such as TNF-a have also been shown to induce apoptotic pathways in infected cells. Our work shows that specific cytokines (IL-17, IL-23) local.....
Document: The impact of cytokines on oxidative stress and the UPR can dictate protein biosynthesis. For example, type I interferon signalling has been shown to regulate chronic hepatitis B virus infection via induction of oxidative stress in epithelial cells. [71] [72] [73] [74] Anti-viral effects of other cytokines such as TNF-a have also been shown to induce apoptotic pathways in infected cells. Our work shows that specific cytokines (IL-17, IL-23) locally cause ER stress, particularly in cells with an inherent susceptibility to protein misfolding or inadequate UPR.
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