Author: Subudhi, Sonu; Rapin, Noreen; Misra, Vikram
Title: Immune System Modulation and Viral Persistence in Bats: Understanding Viral Spillover Document date: 2019_2_23
ID: 1bi6q127_29
Snippet: Secondary infections in humans are immunologically stressful [58] . Little brown bats are particularly susceptible to a frequently lethal fungal infection known as the white nose syndrome, caused by Pseudogymnoascus destructans [59] [60] [61] . A study looking at the effects of white-nose syndrome fungus on a persistently infecting coronavirus showed that bats having the fungal infection in wings had 60 times more coronavirus in their intestines .....
Document: Secondary infections in humans are immunologically stressful [58] . Little brown bats are particularly susceptible to a frequently lethal fungal infection known as the white nose syndrome, caused by Pseudogymnoascus destructans [59] [60] [61] . A study looking at the effects of white-nose syndrome fungus on a persistently infecting coronavirus showed that bats having the fungal infection in wings had 60 times more coronavirus in their intestines as compared to fungal uninfected bats [62] . The intestines of the fungus-infected bats exhibited a gene expression profile suggesting suppression of the innate antiviral response, which may have contributed to unrestrained viral replication. This suggests that secondary infections in bats persistently infected with viruses could increase the potential of viral shedding.
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