Author: Tang, Fang; Liu, Wei; Zhang, Fang; Xin, Zhong-Tao; Wei, Mao-Ti; Zhang, Pan-He; Yang, Hong; Ly, Hinh; Cao, Wu-Chun
Title: IL-12 RB1 Genetic Variants Contribute to Human Susceptibility to Severe Acute Respiratory Syndrome Infection among Chinese Document date: 2008_5_14
ID: 01o15wd4_16
Snippet: Pairwise linkage disequilibrium (LD) analysis of the four SNPs showed strong LD among +705 A/G, +1158T/C and +1196G/C To investigate if a particular haplotype constituted by these SNPs was associated with the disease, haplotype frequencies were estimated and association analysis was performed using multiple logistic regression with age, sex and infection source being the covariants. As shown in Table 4 , the frequency of GCCT haplotype in SARS pa.....
Document: Pairwise linkage disequilibrium (LD) analysis of the four SNPs showed strong LD among +705 A/G, +1158T/C and +1196G/C To investigate if a particular haplotype constituted by these SNPs was associated with the disease, haplotype frequencies were estimated and association analysis was performed using multiple logistic regression with age, sex and infection source being the covariants. As shown in Table 4 , the frequency of GCCT haplotype in SARS patients (26.6%) was significantly increased when compared to the control A group (11.1%), but when compared to the control B group, the proportions of this haplotype in the two groups were not different (26.6% in SARS patients vs. 22 .3% in controls).
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