Author: Marcotullio, Maria Carla; Pelosi, Azzurra; Curini, Massimo
Title: Hinokinin, an Emerging Bioactive Lignan Document date: 2014_9_17
ID: 04kh4yzy_37
Snippet: Nowadays, it is well established that neurons and glia development is regulated by neurotransmitters. Monoamine neurotransmitters such as dopamine, norepinephrine and serotonine have a positive action as classical growth factors, while glutamate and GABA (γ-aminobutyric acid) are down-regulating proliferation agents [104] . Hinokinin (1) showed neuroprotective activity against glutamate induced neurotoxicity in primary cultures of rat cortical c.....
Document: Nowadays, it is well established that neurons and glia development is regulated by neurotransmitters. Monoamine neurotransmitters such as dopamine, norepinephrine and serotonine have a positive action as classical growth factors, while glutamate and GABA (γ-aminobutyric acid) are down-regulating proliferation agents [104] . Hinokinin (1) showed neuroprotective activity against glutamate induced neurotoxicity in primary cultures of rat cortical cells (at 1.0 μM percentage of protection 42.6 ± 2.4, at 10.0 μM 56.9 ± 3.4; dizocipline maleate, a non-competitive antagonist of NMDA (N-methyl-D-aspartate) receptor (one of the glutamate receptors) showed at 1.0 μM 71.7 ± 1.2 and at 10.0 μM 77.4 ± 2.1 percentage of protection) [105] . Furthermore, Timple et al. demonstrated that hinokinin is a selective inhibitor of human dopamine and norepinephrine transporters in a noncompetitive manner with a low affinity for the serotonine transporter [106] .
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