Author: Bekpen, Cemalettin; Tautz, Diethard
Title: Human core duplicon gene families: game changers or game players? Document date: 2019_9_16
ID: 0fjh10v7_18
Snippet: The RANBP2 protein encoded by the progenitor gene is primarily localized within the periphery of the nuclear envelope and is thought to be required for cargo import and export [37] . Hence, the RGPD gene family members may be modifiers of this function. Interestingly, RANBP2 was also shown to be involved in resistance against Simian Immunodeficiency Virus [38] . It is thus possible that the expansion of RGPD genes is the result of an arms race be.....
Document: The RANBP2 protein encoded by the progenitor gene is primarily localized within the periphery of the nuclear envelope and is thought to be required for cargo import and export [37] . Hence, the RGPD gene family members may be modifiers of this function. Interestingly, RANBP2 was also shown to be involved in resistance against Simian Immunodeficiency Virus [38] . It is thus possible that the expansion of RGPD genes is the result of an arms race between virus evolution and host resistance acquisition. The Ranbp2 knockout in mice is homozygous lethal.
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