Author: Subudhi, Sonu; Rapin, Noreen; Misra, Vikram
Title: Immune System Modulation and Viral Persistence in Bats: Understanding Viral Spillover Document date: 2019_2_23
ID: 1bi6q127_33
Snippet: Although there is some evidence for the increase in virus replication and shedding in bats under stress, a direct link of this to spillover events has yet to be discovered. Future controlled experiments aimed at studying transmission dynamics in the presence and absence of stress in bats would lead to a more definitive answer. It is also important to look into various factors that might stress bats such as habitat destruction (deforestation), pre.....
Document: Although there is some evidence for the increase in virus replication and shedding in bats under stress, a direct link of this to spillover events has yet to be discovered. Future controlled experiments aimed at studying transmission dynamics in the presence and absence of stress in bats would lead to a more definitive answer. It is also important to look into various factors that might stress bats such as habitat destruction (deforestation), pregnancy, change in seasons, and climate change. Additionally, the molecular mechanisms leading to the waning of antibodies and other aspects of adaptive immune response in bats are not known. A holistic picture of bat immune systems and the factors leading to an increase in viral replication might help us further understand viral spillovers.
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