Author: Vidaña, Beatriz; Martínez, Jorge; Martínez-Orellana, Pamela; García Migura, Lourdes; Montoya, María; Martorell, Jaime; Majó, Natàlia
Title: Heterogeneous pathological outcomes after experimental pH1N1 influenza infection in ferrets correlate with viral replication and host immune responses in the lung Document date: 2014_8_28
ID: 0hyg403m_56
Snippet: In the present study, CD3+ and CD8+ cells were found more abundantly in the ferrets that exhibited severe lesional pattern that were accompanied with elevations in the inductions of IFNγ, CCL5 and CCL3. Several studies have shown that NK and CD8 T cells concentrations increase in mouse and human lungs following severe influenza infection both in the early stages of influenza infection and the later viral clearance stage [41, [45] [46] [47] [48] .....
Document: In the present study, CD3+ and CD8+ cells were found more abundantly in the ferrets that exhibited severe lesional pattern that were accompanied with elevations in the inductions of IFNγ, CCL5 and CCL3. Several studies have shown that NK and CD8 T cells concentrations increase in mouse and human lungs following severe influenza infection both in the early stages of influenza infection and the later viral clearance stage [41, [45] [46] [47] [48] [49] . Moreover, the suppression of the early innate cell infiltration of NK and CD8 T cells has been shown to significantly increase mouse survival rates without altering the kinetics of viral clearance; these findings suggest that the infiltration of these cells has a negative inflammatory role that is independent of viral kinetics [50, 51] .
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