Author: Vidaña, Beatriz; Martínez, Jorge; Martínez-Orellana, Pamela; García Migura, Lourdes; Montoya, María; Martorell, Jaime; Majó, Natàlia
Title: Heterogeneous pathological outcomes after experimental pH1N1 influenza infection in ferrets correlate with viral replication and host immune responses in the lung Document date: 2014_8_28
ID: 0hyg403m_8
Snippet: The pH1N1 2009 subtype isolates A/CastillaLaMancha/ RR5661/2009 and A/CastillaLaMancha/RR5911/2009 were isolated from respiratory samples of two patients who were both Caucasian and free of previous co-morbid conditions at the time of infection. Hereafter, the following designations will be used: virus R61 for the A/CastillaLaMancha/ RR5661/2009 virus, which was isolated from a 23-year old man exhibiting mild respiratory disease, and virus R11 fo.....
Document: The pH1N1 2009 subtype isolates A/CastillaLaMancha/ RR5661/2009 and A/CastillaLaMancha/RR5911/2009 were isolated from respiratory samples of two patients who were both Caucasian and free of previous co-morbid conditions at the time of infection. Hereafter, the following designations will be used: virus R61 for the A/CastillaLaMancha/ RR5661/2009 virus, which was isolated from a 23-year old man exhibiting mild respiratory disease, and virus R11 for the A/CastillaLaMancha/RR5911/2009 virus, which was isolated from a 35-year old woman who developed a severe disease that resulted in a fatal outcome. Both viruses were isolated via bronchoalveolar lavage as described by RodrÃguez et al. [11] and were passaged three times in Madin-Darby Canine kidney (MDCK) cells. The R61 virus had a titre of 10 8.3 50% Tissue Culture Infective Dose (TCID 50 ) per mL, and the R11 virus had a titre of 10 8.2 TCID 50 /mL as determined with the Reed and Muench method [25] .
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