Author: Zheng, Yueming; Zhu, Xuejing; Zhou, Pingzheng; Lan, Xi; Xu, Haiyan; Li, Min; Gao, Zhaobing
Title: Hexachlorophene Is a Potent KCNQ1/KCNE1 Potassium Channel Activator Which Rescues LQTs Mutants Document date: 2012_12_12
ID: 1manzf3l_1
Snippet: KCNQ (or Kv7) channels are voltage-gated potassium channels. They mediate sub-threshold, noninactivating voltage-gated potassium currents that have important roles in controlling membrane excitability [1] . Of the five known isoforms, KCNQ1-5, KCNQ1 is the only one predominantly expressed in heart. KCNQ1 is the pore forming subunit, tetrameric KCNQ1 complexes give rise to functional channels. In native cells such as cardiomyocytes, KCNQ1 coassemb.....
Document: KCNQ (or Kv7) channels are voltage-gated potassium channels. They mediate sub-threshold, noninactivating voltage-gated potassium currents that have important roles in controlling membrane excitability [1] . Of the five known isoforms, KCNQ1-5, KCNQ1 is the only one predominantly expressed in heart. KCNQ1 is the pore forming subunit, tetrameric KCNQ1 complexes give rise to functional channels. In native cells such as cardiomyocytes, KCNQ1 coassembles with a non-conductive accessory KCNE1 subunit, a small single transmembrane protein encoded by KCNE1 gene. The heteromultimeric KCNQ1/ KCNE1 was proposed to mediate a slowly activating current that accelerates the repolarization of action potential in cardiac tissues, also known as IKs [2, 3] .
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