Author: Wang, Ran; Moniruzzaman, Md.; Shuffle, Eric; Lourie, Rohan; Hasnain, Sumaira Z
Title: Immune regulation of the unfolded protein response at the mucosal barrier in viral infection Document date: 2018_4_3
ID: 07dlf3zw_25
Snippet: Balanced and integrated ER stress and UPR signalling are crucial in maintaining intestinal mucosal homeostasis, and the immune system can either alleviate or aggravate ER stress. 55 IL-10 produced by regulatory T cells can suppress ER stress by inhibiting the translocation of ATF6p50 to the nucleus and downstream p38 mitogenactivated protein kinase (MAPK) activation in intestinal epithelial cells. 56 This maintains mucin production in goblet cell.....
Document: Balanced and integrated ER stress and UPR signalling are crucial in maintaining intestinal mucosal homeostasis, and the immune system can either alleviate or aggravate ER stress. 55 IL-10 produced by regulatory T cells can suppress ER stress by inhibiting the translocation of ATF6p50 to the nucleus and downstream p38 mitogenactivated protein kinase (MAPK) activation in intestinal epithelial cells. 56 This maintains mucin production in goblet cells, preserving the mucus barrier and reducing further immune activation. 54 Another regulatory-related cytokine IL-22 reduces high-fat diet-associated oxidative and ER stress in intestinal epithelial cells and subsequent intestinal inflammation to improve mucosal barrier function. 52
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