Author: Wang, Ran; Moniruzzaman, Md.; Shuffle, Eric; Lourie, Rohan; Hasnain, Sumaira Z
Title: Immune regulation of the unfolded protein response at the mucosal barrier in viral infection Document date: 2018_4_3
ID: 07dlf3zw_30
Snippet: mechanism that block arms of the UPR. Innate cytokines are released quickly and dynamically. We identified selected cytokines that have a direct downstream chemical effect within the ER, which induces misfolding of viral proteins regardless of any viral blocking of the UPR ( Figure 5 ). Translated viral proteins will misfold due to the inappropriate oxidative state in the ER, leading to host cell apoptosis and reduced virulence......
Document: mechanism that block arms of the UPR. Innate cytokines are released quickly and dynamically. We identified selected cytokines that have a direct downstream chemical effect within the ER, which induces misfolding of viral proteins regardless of any viral blocking of the UPR ( Figure 5 ). Translated viral proteins will misfold due to the inappropriate oxidative state in the ER, leading to host cell apoptosis and reduced virulence.
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