Author: Wang, Ran; Moniruzzaman, Md.; Shuffle, Eric; Lourie, Rohan; Hasnain, Sumaira Z
Title: Immune regulation of the unfolded protein response at the mucosal barrier in viral infection Document date: 2018_4_3
ID: 07dlf3zw_30
Snippet: mechanism that block arms of the UPR. Innate cytokines are released quickly and dynamically. We identified selected cytokines that have a direct downstream chemical effect within the ER, which induces misfolding of viral proteins regardless of any viral blocking of the UPR ( Figure 5 ). Translated viral proteins will misfold due to the inappropriate oxidative state in the ER, leading to host cell apoptosis and reduced virulence......
Document: mechanism that block arms of the UPR. Innate cytokines are released quickly and dynamically. We identified selected cytokines that have a direct downstream chemical effect within the ER, which induces misfolding of viral proteins regardless of any viral blocking of the UPR ( Figure 5 ). Translated viral proteins will misfold due to the inappropriate oxidative state in the ER, leading to host cell apoptosis and reduced virulence.
Search related documents:
Co phrase search for related documents- cell apoptosis and viral blocking: 1
- cell apoptosis and viral protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- reduce virulence and viral protein: 1
- translate viral protein and viral protein: 1
- UPR arm and viral protein: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date