Author: Smith, Steven B.; Dampier, William; Tozeren, Aydin; Brown, James R.; Magid-Slav, Michal
Title: Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis Document date: 2012_3_14
ID: 100ir651_33
Snippet: Interleukin 1 beta (IL1B). IL1B is a cytokine involved in inflammatory response, cell proliferation, differentiation, and apoptosis. IL1B is specifically cleaved into its active form by the protease CASP1 after which it activates the NLRP3 inflammasome [29] [30] [31] 69] . Indeed, IL1B is consistently up regulated across CMV, FLU, HRV, MPENU and RSV which likely correlates with inflammasome activation. However, overexpression of IL1B causes multi.....
Document: Interleukin 1 beta (IL1B). IL1B is a cytokine involved in inflammatory response, cell proliferation, differentiation, and apoptosis. IL1B is specifically cleaved into its active form by the protease CASP1 after which it activates the NLRP3 inflammasome [29] [30] [31] 69] . Indeed, IL1B is consistently up regulated across CMV, FLU, HRV, MPENU and RSV which likely correlates with inflammasome activation. However, overexpression of IL1B causes multiple inflammatory disorders [69] . Antagonists or neutralizers of IL1B, such as Canakinumab, could potentially reduce inflammation damage associated with viral infection.
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