Author: Smith, Steven B.; Dampier, William; Tozeren, Aydin; Brown, James R.; Magid-Slav, Michal
Title: Identification of Common Biological Pathways and Drug Targets Across Multiple Respiratory Viruses Based on Human Host Gene Expression Analysis Document date: 2012_3_14
ID: 100ir651_40
Snippet: However, caspases are not specific to the Parkin-UPS pathway and inhibition in this regard may result in toxicity or other complications [88] . Additionally, mouse JAX phenotypes for CASP1 show both increased and decreased susceptibility to bacterial infection, as well as decreased inflammatory response. While CASP1 inhibition may prove beneficial in terms of increasing inflammatory responses, it is ambiguous in terms of benefit for bacterial inf.....
Document: However, caspases are not specific to the Parkin-UPS pathway and inhibition in this regard may result in toxicity or other complications [88] . Additionally, mouse JAX phenotypes for CASP1 show both increased and decreased susceptibility to bacterial infection, as well as decreased inflammatory response. While CASP1 inhibition may prove beneficial in terms of increasing inflammatory responses, it is ambiguous in terms of benefit for bacterial infections. In our analysis, the expression of CASP1 and TUBB3 is also somewhat variable across virus types. Therefore, more study is needed specifically on the role of caspase and tubulin in host response to respiratory virus infection.
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