Author: M. Gordon Joyce; Rajeshwer S. Sankhala; Wei-Hung Chen; Misook Choe; Hongjun Bai; Agnes Hajduczki; Lianying Yan; Spencer L. Sterling; Caroline E. Peterson; Ethan C. Green; Clayton Smith; Natalia de Val; Mihret Amare; Paul Scott; Eric D. Laing; Christopher C. Broder; Morgane Rolland; Nelson L. Michael; Kayvon Modjarrad
Title: A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein Document date: 2020_3_17
ID: ebbzx8yr_9
Snippet: The CR3022 heavy chain is encoded by IGHV5-51*03, contains a 12-aa CDR H3 with 8 V gene-encoded residues altered by somatic hypermutation. CR3022 light chain is encoded by IGKV4-1*01 with 1 V geneencoded residue, altered by somatic hypermutation, and a 9-aa CDR L3 (Extended Data Figure 2A ). To provide an atomic-level understanding of the structure of the CR3022 antibody, we crystallized the antigenbinding fragment (Fab) of CR3022. Crystals diffr.....
Document: The CR3022 heavy chain is encoded by IGHV5-51*03, contains a 12-aa CDR H3 with 8 V gene-encoded residues altered by somatic hypermutation. CR3022 light chain is encoded by IGKV4-1*01 with 1 V geneencoded residue, altered by somatic hypermutation, and a 9-aa CDR L3 (Extended Data Figure 2A ). To provide an atomic-level understanding of the structure of the CR3022 antibody, we crystallized the antigenbinding fragment (Fab) of CR3022. Crystals diffracted to 3.2 Ã… resolution in space group P 21 (Table 1) .
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